May 09, 2012 in eight lymphoma patients who received highdose methotrexate, gcsfbased mouthwash decreased the severity of oral mucositis compared with placebo. Id adobe reader adalah penampil file pdf yang dapat membuka dan berinteraksi dengan semua dokumen pdf. Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer. Preventing mucositis not only exposure radiation, but also by taking active measures. Mucositis adalah ketika mulut atau bagian usus terasa sakit dan meradang, hal ini merupakan efek samping yang umum dari kemoterapi dan radioterapi untuk kanker.
Mucositis because it is an inflammation of the mucous membranes it includes the symptoms of redness, pain and ulceration in the affected area. Hdl adalah kolesterol yang bermanfaat bagi tubuh manusia, fungsi dari hdl yaitu mengangkut ldl didalam jaringan perifer ke hepar akan membersihkan lemaklemak yang menempel di pembuluh darah yang kemudian akan dikeluarkan melalui saluran empedu dalam bentuk lemak empedu sutanto, 2010. In severe cases, oral mucositis may be treatmentlimiting, causing a reduction in dosage or delays in the delivery of therapy. Mutasi adalah perubahan materi genetik gen atau kromosom suatu sel yang diwariskan kepada keturunannya. Nurses can assist patients to manage oral pain and other side effects that. Among these, the most frequent are dry mouth hyposalivation, dysgeusia, and stomatitis. The outcomes highlighted by nice should apply to any effective mucositis treatment. Mencegah oral mucositis akibat kemoterapi pada anak dengan. Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients.
Introduction mucositis occurs when cancer treatments break down the rapidly divided epithelial cells lining the gastrointestinal tract which goes from the mouth to the anus, leaving the mucosal tissue open to ulceration and infection. Oral mucositis is one of the main complications in. Oral mucositis is inflammation in and around your mouth. When ulcers show typical clinical findings, differential diagnosis may be easy. Sites of mucositis while the oral mucosa is the most frequent site of mucosal toxicity, mucositis also is common along the entire alimentary tract.
Tanpa pengobatan yang adekuat, dapat menyebabkan meningitis dan abses otak. Since duration of significant mucositis is the most important driver of untoward outcomes of mucositis, less than daily assessment is risky, especially in clinical trials. Common terminology criteria for adverse events ctcae version 5. Jun 27, 2015 oral mucositis om is a major limiting acute side effect of radiotherapy for head and neck cancer.
Oral mucositis is a condition that is characterized by ulcerative. Tujuan penelitian ini adalah untuk mengetahui gambaran dan tingkat keparahan mukositis oral setelah dilakukan radioterapi kanker nasofaring. Wo2008011085a1 compositions and methods for the treatment. Minimal mucositis if oral cavity dose 34 gy andor oral cavity dose 39 gy results in longduration of mucositis. The second case, oral mucositis grade i and oral candidiasis were found in a 55year old man suffering from nasopharyngeal cancer stage iv who has been treated 10 times with chemotherapy and radiotherapy. Mucosal tissue injury is a doselimiting side effect and also limits nutritional intake and oral function, resulting in weight loss and nutritional deficits for many patients. Prophylaxis with gmcsf mouthwashes does not reduce frequency and duration of severe oral mucositis in patients with solid tumors undergoing highdose chemotherapy with autologous peripheral blood stem cell transplantation rescue. The effect on ulceration and diarrhoea severity can be quantified over the following days. Nov 16, 2012 sites of mucositis while the oral mucosa is the most frequent site of mucosal toxicity, mucositis also is common along the entire alimentary tract. Mucositis is also defined as inflammatory lesions of the oral andor gastrointestinal tract caused by highdose cancer therapies. Severe oral mucositis can be very painful leading to decreased intake of food and drink and clinically significant weight loss or dehydration fig. Berarti tujuan akhir pendidikan kesehatan adalah agar masyarakat dapat mempraktekan hidup sehat bagi dirinya sendiri dan bagi masyarakat dapat berperilaku hidup sehat.
Oral ulceration a portal for infection and septicemia. Oral ulcers are common symptoms observed in the oral cavity and include traumatic, infective, aphthous, ulceration related to dermatoses, druginduced, ulceration as a manifestation of systemic disease, and ulceration due to malignancy 4, 5, 6. The sores also leave patients open to potentially lifethreatening infections. Mukositis oral dan kualitas hidup spesifikmukositis oral. Participate in an interactive discussion on assessment and oral care for oncology patients in all settings. By alleviating or lessening oral mucositis patient may be able to receive the needed dose of radiation or chemotherapy to cure and control the cancer.
Oral mucositis developed in 22% of 1236 cycles of chemotherapy, gi mucositis in 7% of cycles and both. Karena jika dibiarkan kondisi ini akan membuat mucositis menjadi lebih buruk. Mucositis can occur anywhere along the gastrointestinal gi tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. Doc penanganan oral mucositis pada pasien dengan kanker. Pdf oral mucositis is an inflammatory process and ulcerative of the oral mucosa due to chemotherapy andor radiotherapy. Patients with oral mucositis are significantly more likely to experience severe pain and weight loss8. The person who has dry mouth when taking treatment for cancer will have more risk for getting mucositis than others. It is in addition the chief source of pain for patients who go through transplants for the bone marrow. Pdf guidelines for the assessment of oral mucositis in. Download as ppt, pdf, txt or read online from scribd.
Mukositis oral merupakan lesi yang ditandai dengan lapisan putih kekuningan, berbentuk difus, eritema pada permukaan mukosa dan disertai dengan rasa sakit yang timbul selama menjalani radioterapi kanker. Otot mempunyai selsel yang tipis dan panjang yang mengubah energi yang tersimpan dalam lemak dan gula darah glukosa menjadi gerakan dan panas. Mikosis umumnya menyerang orang dengan sistem imun yang lemah ada berbagai jenis jamur yang dapat menyebabkan infeksi pada manusia, dan beberapa jenis jamur dapat menyerang lebih dari satu bagian tubuh yang berbeda. Mucositis occurs when cancer treatments break down the rapidly divided epithelial cells lining the gi tract, particularly in the oral cavity, leaving the mucosal tissue open to ulceration and infection. Keparahan mukositis oral pada pasien kanker kepala leher. I would like to add that, after reading the mucositis page, i decided that my post on 25 may could be written more neutrally. From july 1997 through june 1998, 17 patients with head and neck cancer receiving primary or adjuvant irradiation were randomized to either glutamine suspension 16 g in 240 ml normal saline n 8 or placebo normal saline n 9 arm. Radiografi adalah alat yang digunakan dalam diagnosis danpengobatan penyakit baik penyakit umum maupun penyakit mulut tertentu. The morbidity or oral mucositis, includes pain, nutritional compromise, decreased quality of life, alteration in cancer therapy, risk of infection and economic costs. Educational objectives after completion of this activity, participants should be able to. Mucous membranes are mucousproducing moist inner linings present in some organs and body cavities such as the digestive system.
Sinergi antara bakteri dan jamur tertentu mungkin juga memainkan peran penting dalam merusak pertahanan tubuh. Oral mucositis om is a common side effect in patients with cancer treated with chemotherapy andor radiotherapy. With prevalence between 10% and 100%, depending of the cytotoxic regimen and patientassociated variables, this morbid condition represents a significant problem in oncology. Chronic mucositis following the completion of radiationtherapy is rarely seen. Complutense university, spain antiseptic mouth rinse vs placebo randomized. Oral mucositis, the breakdown of the mucosal lining of the oropharynx, occurs as a result of a toxic insult to the normal epithelium of the oral mucosa. Kebersihan rongga mulut adalah syarat utama dari perawatan. The cytotoxic insult is administered and mucositis gradually develops. Mucositis can be classified according to the type of cancer therapy involved as chemotherapyinduced mucositis, radiationinduced mucositis, or a combination of the two. Radioterapi dapat mematikan selsel tumor dengan cara merusak materi genetik dna dan apabila radioterapi dilakukan dalam dosis yang tinggi secara bertahap dan berulangulang. Summary patients receiving highdose chemotherapyhdct are at risk of severe mucositis.
Patients with severe mucositis may need intravenous nutrition, antibiotics to fight infections, pain medicines, and longer hospital stays. Oral ulcerations due to drug medications sciencedirect. Pdf identifikasi dan pengendalian faktor risiko mukositis. Download adobe acrobat reader terbaru gratis dc 2020. Non odontogenic infection immunology health sciences.
It begins 510 days after the initiation of chemotherapy and lasts 714 days. Management of chemoradiationinduced oral mucositis in. Gastrointestinal mucosal injury mucositis, commonly affecting the oral cavity, is a clinically significant yet incompletely understood. Gunakan adobe reader untuk melihat, mencari, verifikasi, mencetak, dan berkolaborasi pada file adobe pdf. Poor dental care, or dentures that do not fit well. Mucositis symptoms, diagnosis, treatments and causes. Tujuannya adalah untuk melindungi area ulserasi, mengurangi rasa nyeri dan mengurangi peradangan.
Mucositis is a major side effect induced by chemotherapy and radiotherapy. Oral mucositis is a painful inflammation and ulceration of the mucosal membranes in the mouth. Chemotherapy and radiation therapy to treat cancer. Chemotherapy, radiation and targeted therapies can affect the ability of cells to reproduce, slowing healing of the oral mucosa. Why does mucositis matter bmt ctn 0401 will intervention make mucositis worse bmt ctn 0402 will intervention make mucositis better. Chemotherapyinduced oral mucositis causes the mucosal lining of the mouth to atrophy and break down, forming ulcers. Assessment and grading of oral mucositis after stem cell. Hasil menunjukkan ratarata responden berusia 6,55 tahun, mayoritas berjenis kelamin lakilaki dan. A comparison and assessment of scoring scales for mucositis. The effect of oral management on the severity of oral mucositis during hematopoietic stem cell transplantation hsct kenji yamagata phd1, chie arai1, hiroyoshi sasaki 1, yasutoshi takeuchi2, kojiro onizawa phd1, toru yanagawa ph d 1, naomi ishibashi1, rei karube 1, keiji shinozuka ph d1, yuichi. The invention relates to methods of treating mucositis comprising administering a compound of formula a, compound of any one of formulae 1 to 46, lipoxin compound, or oxylipin compound. Management of oral mucositis in patients with cancer. Effect of oral cryotherapy on combination chemotherapyinduced oral mucositis.
The 2016 world health organization classification of. Mucositis definition of mucositis by medical dictionary. Discuss the early recognition and assessment of oropharyngeal. Radiation therapy or chemotherapy may cause mucositis. Guideline for the prevention of oral and oropharyngeal. Answer mucositis is a condition in which mouth sores develop after chemotherapy destroys the mucosal cells that line the mouth and intestinal tract.
Stomatitis is a general term for disturbance of oral epithelial cells and covers several types of oral mucosal symptoms. A history of poor nutrition or a diet low in vitamins. Sinergi seperti itu mungkin terdapat antara b fagilis dan bakteri gram negatif terutama e coli, dimana koinvokulasi. For years, doctors wondered what could be done to relieve oral mucositis in patients receiving cancer treatment. Common terminology criteria for adverse events ctcae. Oral leukoedema with mucosal desquamation caused by. Mucositis is the effect of modern cellkilling treatment for cancer patients.
Chemotherapyinduced oral mucositis is associated with detrimental. Relieving oral mucositis national cancer institute. The 2016 world health organization classification of tumors of the central nervous system. Kanker nasofaring merupakan salah satu jenis kanker kepala dan leher yaitu tumor ganas pada bagian nasal dan faring yang berasal dari sel epitel nasofaring. It presents a significant burden not only to patient quality of life but also may result in diminished tumor control through dose reductions and increased treatment costs due to extended. Oral mucositis om is an inflammatory reaction of the oropharyngeal mucosa to. In this paper we address oral mucositis and discuss its pathobiology, risk factors, impact and management in view of the most recent evidence. To evaluate the influence of oral glutamine on radiationinduced oral mucositis in the radiotherapy of head and neck cancer. After that, symptoms of oral mucositis can then persist for up to 8 weeks. Follow your health care providers instructions on how to care for your mouth.
Oral mucositis is a significant toxicity of systemic chemotherapy and radiotherapy to the head and neck. Tanda dan gejala oral mucositis adalah nyeri pada mulut, eritema, kesulitan. Mucositis pain is a major clinical problem associated with cancer treatment. Incidence of mucositis is increased with addition of concurrent chemotherapy as well as altered fractionation schedules. Although mucositis is a leading cause of morbidity and mortality in cancer patients. The painful component associated with moderatesevere oral mucositis can be sufficiently severe so as to cause reduction of chemotherapy doses in subsequent multicycle regimens and temporary or permanent interruption of radiation therapy6, 7. In one study, it was reported that 303 of 599 patients 51 % receiving chemotherapy for solid tumors or lymphoma developed oral andor gi mucositis 3. Oral mucositis is a significant problem in patients undergoing chemotherapeutic management for solid tumors.
These therapies are indicated for patients with cancer, and those affected with mucositis are cancer patients. Healing begins soon after the completion of the treatment. Effect of cryotherapy on combination chemotherapyinduced. Summary patients describe oral mucositis as the most painful and debilitating symptoms associated with cancer treatment. Download pdf mucositis management for patients treated with chemotherapy print on 8. The lite therapy effectiveness for oral mucositis liteform trial will discover if lowlevel laser treatment can help in the management of painful irritation of the mouth lining a common and very unpleasant side effect of chemotherapy and radiotherapy. Mucositis or also known as oral and gastrointestinal mucositis is a condition that develops right after the start of chemotherapy or radiation therapy. Bagian yang disebut mukosa mulut, adalah salah satu bagian tubuh yang paling sensitif dan sangat rentan terhadap kemoterapi dan radiasi. The guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation was endorsed by the cog supportive care guideline committee in february 2016. Trauma radioterapi chemotherapy mucositis salivary gland infections common in patients with dehydration lymph node abscess post operative infections mikroorganisme penyebab infeksi non.
Dalam kaitannya dengan perawatan halitosis agar dapat dipergunakan misalnya dalam bentuk bahan kumur mulut, perlu dilakukan stabilisasi agar tidak mudah menguap dan tidak menjadi aktif sebelum dipergunakan. Mutasi dapat disebabkan oleh kesalahan replikasi materi genetika selama pembelahan sel oleh radiasi, bahan kimia mutagen, atau. Describe the pathophysiology, clinical manifestations, prevention, and treatment of oropharyngeal mucositis. It results from the systemic effects of cytotoxic chemotherapy agents and from the local effects of radiation to the oral mucosa. In addition, rampant dental caries may develop in patients treated with radiation in. Bab ii tinjauan pustaka anatomi dan fisiologi sistem. Mucositis can occur anywhere along the digestive tract from the mouth to the anus, leaving the mucosal tissue open to ulceration and infection.
Pdf effect of oral cryotherapy on combination chemotherapy. Mycoses atau mikosis adalah infeksi jamur yang dapat menyerang permukaan dan lapisan kulit hingga organ dalam tubuh manusia. Mucosal tissue, also known as mucosa or the mucous membrane, lines all body passages that communicate with the air, such as the. The effects on apoptosis and cell proliferation in a given cell population can be quantified within hours of irradiation. Mucositis can occur anywhere along the gastrointestinal tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. Mucositis is an inflammatory reaction of the mucosa of the alimentary tract at caused by chemotherapy, radiotherapy, and targeted therapy for cancer. Pdf oral mucositis severity in patient with head and. Managing oral mucositis cancer therapy oral health group.
Mastoiditis adalah infeksi bakteri pada tulang mastoid. Mutasi dapat disebabkan oleh kesalahan replikasi materi genetika selama pembelahan sel oleh radiasi, bahan kimia mutagen, atau virus, atau dapat terjadi selama proses meiosis. Mucositis is further complicated by nausea and vomiting which often occurs with treatment. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Adobe acrobat reader dc memungkinkan anda melihat dan mencetak file dalam bentuk portable document format atau yang lebih dikenal dengan nama pdf. Most prevention studies evaluate the degree of mucositison. Gastrooesophageal reflux disease gerd adalah salah satu kelainan yang sering dihadapi di lapangan dalam bidang gastrointestinal. Pdf oral mucositis om is one of the main complications of patients. Otot adalah sebuah jaringan yang terbentuk dari sekumpulan selsel yang berfungsi sebagai alat gerak. Esophagus duodenum colon stomach ileumjejunum rectum gi mucositis occurs via a mechanism similar to that in the oral mucosa, only the damage to the mucosal layer is more. Mucositis can occur anywhere along the digestive tract from the mouth to the anus as it is all lined with mucous membranes. The duration mucositis takes to heal depends on the dose intensity of the radiotherapy, but usually, healing is complete within 3 weeks after the end of treatment. Oral glutamine to alleviate radiationinduced oral mucositis. The effect of oral management on the severity of oral. As we have come to understand its pathogenesis new developments in its management and prevention have allowed us minimize this side effect. Radiation oncologytoxicitymucositis wikibooks, open books. Oral mucositis is a common complication of cancer chemotherapy.
Young people are at risk of getting oral mucositis. More recently, mucositis following targeted anticancer therapies has been described, but our understanding of that is only beginning to develop. The spectrum of problems associated with mucositis includes oral pain, odynophagia, reduced oral intake, and secondary infections. Strategi yang digunakan dalam menentukan sampel adalah consecutive sampling berjumlah 2 orang. Many kinds of adverse reactions induced by drug medications in the oral cavity are now well recognized 1, 2, 3. Mucositis in cancer patients introduction oral mucositis, also called stomatitis, is a common, debilitating complication of cancer chemotherapy and radiotherapy, occurring in about 40% of patients. Nearly all patients treated with highdose chemotherapy requiring haematopoietic stem cell or bone marrow transplantation develop om of varying severity. The 2016 world health organization classification of tumors. Mucositis definition, symptoms, grading, treatment, pictures. Oral mucositis is a common complication of cancer therapy which may limit the completion of treatment and affect the quality of life of the patient. Aids, diabetes, kidney disease, or other longterm illnesses.
Mucositis can occur anywhere along the gastrointestinal gi tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in. Oral leukoedema with mucosal desquamation caused by toothpaste containing sodium lauryl sulfate. The multinational association of supportive care in cancerinternational society of oral oncology masccisoo is a partnership between two. Oral mucositis akibat kemoterapi menyebabkan lapisan mukosa mulut atrofi dan pecah membentuk ulser. Kanker nasofaring dapat diobati dengan radioterapi. Masthead postal and contact information volume 6 supplement 1 journal of the national comprehensive cancer network jnccn jnccn issn 15401405, the official journal of the national comprehensive cancer network, is pub lished 10 times annually by jones and bartlett publishers, 40 tall pine drive, sudbury, ma 01776. It is a frequent side effect of cancer treatment with radiation and chemotherapy. Data dikumpulkan melalui penyebaran kuesioner yaitu oral mucositis daily questionnaire omdq dan oral mucositisspecific quality of life omqol. Biasanya didahului oleh oma yang tidak mendapatkan pengobatan adekuat. Assessment of cancer therapyinduced oral mucositis using a.
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